Ngokungafaniyo nezinye izitofu ezininzi zokugonya eziqulethe intsholongwane yentsholongwane okanye inxalenye yayo, izitofu zokugonya zentsholongwane egazini zisebenzisa intsholongwane engenabungozi ukuhambisa iqhekeza lekhowudi yemfuza kwiiseli zethu, ezivumela ukuba zenze iprotheni yepathogen.Oku kuqeqesha amajoni ethu omzimba ukuba asabele kusulelo oluzayo.
Xa sinosulelo lwebhaktheriya okanye lwentsholongwane, amajoni ethu omzimba asabela kwiimolekyuli ezivela kwi-pathogen.Ukuba kukudibana kwethu okokuqala nomhlaseli, inkqubo elungelelanisiweyo elungelelanisiweyo idibana ukulwa i-pathogen kunye nokwakha ukungakhuseleki kukudibana kwexesha elizayo.
Izitofu ezininzi zokugonya zemveli zihambisa i-pathogen eyosulelayo okanye inxalenye yayo emizimbeni yethu ukuqeqesha amajoni ethu omzimba ukuba alwe nokuvezwa kwikamva kwi-pathogen.
Izitofu zokugonya iVector yentsholongwane zisebenza ngokwahlukileyo.Basebenzisa intsholongwane engenabungozi ukuhambisa iqhekeza lekhowudi yemfuza ukusuka kwipathogen ukuya kwiiseli zethu ukulinganisa usulelo.Intsholongwane engenabungozi isebenza njengenkqubo yokuhanjiswa, okanye i-vector, kulandelelwano lwemfuza.
Iiseli zethu emva koko zenza iprotein yentsholongwane okanye ibhaktiriya ehanjiswe yivector kwaye ibonise kumajoni ethu omzimba.
Oku kusivumela ukuba siphuhlise i-immune impendulo echasene ne-pathogen ngaphandle kwesidingo sosulelo.
Nangona kunjalo, i-vector yentsholongwane ngokwayo idlala indima eyongezelelweyo ngokunyusa impendulo yethu yomzimba.Oku kukhokelela kwimpendulo eyomeleleyo kunokuba ulandelelwano lwemfuzo lwe-pathogen lunikezelwe ngokwalo.
Isitofu sokugonya se-Oxford-AstraZeneca COVID-19 sisebenzisa i-chimpanzee eqhelekileyo yentsholongwane ebandayo eyaziwa ngokuba yi-ChAdOx1, ehambisa ikhowudi evumela iiseli zethu ukuba zenze i-SARS-CoV-2 spike protein.
Ixesha lokuposa: Mar-24-2021